Novel biodegradable poly(1,8-octanediol malate) for annulus fibrosus regeneration

作者：Wan Yuqing; Feng Gang; Shen Francis H; Balian Gary; Laurencin Cato T; Li Xudong^*

来源：Macromolecular Bioscience, 2007, 7(11): 1217-1224.

DOI：10.1002/mabi.200700053

• annulus fibrosus
• biodegradable
• intervertebral disk
• malic acid
• scaffold
• synthesis
• tissue engineering

A novel elastic scaffold that simulates the deformability of annulus fibrosus (AF) and has good biocompatibility was developed. The scaffold was formed of a malic acid-based polyester poly(1,8-octane diol malate) (POM), which was synthesized by direct polycondensation. The tensile strength of POM gradually increased with the extension of the polymerization time, while the degradation rate decreased. Rat AF cells proliferated on the POM films and maintained their phenotype. The 3D scaffold also supported the growth of the AF cells, as confirmed by Safranin-O and type II collagen staining. POM also demonstrated a good biocompatibility in an in vivo foreign body response assay, an important prerequisite for tissue engineering applications. This' study suggests that elastic POM scaffold may be an ideal candidate for AF tissue engineering.

• 出版日期2007-11-12
• 单位川北医学院