A cohort study of the Copenhagen CF Centre eradication strategy against Staphylococcus aureus in patients with CF

作者：Dalboge Christina Schjellerup^*; Pressler Tacjana; Hoiby Niels; Nielsen Kim Gjerum; Johansen Helle Krogh

来源：Journal of Cystic Fibrosis, 2013, 12(1): 42-48.

DOI：10.1016/j.jcf.2012.06.005

• MRSA
• MSSA
• Anti-staphylococcus treatment
• Treatment effectiveness
• Cystic fibrosis

Background: Staphylococcus aureus is an important pathogen in CF. Centre prevalence of intermittent colonization and chronic S. aureus infections and the effectiveness of an anti-S. aureus eradication strategy was assessed.
Methods: All airway cultures from 300 patients in a 2-year period were retrieved and all anti-S. aureus antibiotic treatments were evaluated for treatment success. Chronic infection was defined as a positive culture of S. aureus in 50% or more of the months each year. Change in FEV1 following 2 weeks of treatment of S. aureus was assessed in clinically stable patients. Primary outcome was S. aureus eradication at next clinical visit and number of patients chronically infected.
Results: The yearly prevalence of S. aureus intermittent and chronic infection was 47% and 14%, respectively. Eradication was successful at the next clinical visit in 61% of the standard treatment and 53% of the prolonged treatments, respectively. FEV1 improved significantly following anti-S. aureus treatment (3.3%, p<0.0001).
Conclusion: Our anti-S. aureus eradication strategy in CF patients resulted in a low prevalence of chronic infections and high treatment efficacy. Furthermore, anti-staphylococcal treatment may be associated with a short-term improvement in lung function.

• 出版日期2013-1