No association between the brain-derived neurotrophic factor gene Val66Met polymorphism and tardive dyskinesia in schizophrenic patients

作者：Kang Seung Gul; Choi Jung Eun; An Hyonggin; Lim Se Won; Lee Heon Jeong^*; Han Changsu; Kim Yong Ku; Kim Seung Hyun; Cho Sung Nam; Lee Min Soo; Joe Sook Haeng; Jung In Kwa; Kim Leen

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008, 32(6): 1545-1548.

DOI：10.1016/j.pnpbp.2008.05.016

• brain-derived neurotrophic factor
• polymorphism
• schizophrenia
• tardive dyskinesia

Objective: This study investigated whether the brain-derived neurotrophic factor (BDNF) gene Val66Met single-nucleotide polymorphism (SNP) is associated with antipsychotic-induced tardive dyskinesia (TD) in schizophrenia.
Methods: Genotyping was performed for the BDNF gene Val66Met SNP in Korean schizophrenic patients with (n=83) and without TD (n=126) who were matched for antipsychotic drug exposure and other relevant variables.
Results: The frequencies of genotypes (chi(2)=2.37, p=0.306) and alleles (chi(2)=0.03. p=0.867) did not differ significantly between these two groups.
Conclusion: These findings suggest that the BDNF polymorphism does not play a major role in the susceptibility to TD in schizophrenic patients.

• 出版日期2008-8-1