Cerasome-based gold-nanoshell encapsulating L-menthol for ultrasound contrast imaging and photothermal therapy of cancer

作者：Guan, Qingqing; Wang, Chunan; Wu, Dan; Wang, Wei; Zhang, Chunyang; Liu, Jie; Xu, Ming; Shuai, Xintao; Wang, Zhu^*; Cao, Zhong^*

来源：Nanotechnology, 2019, 30(1): 015101.

DOI：10.1088/1361-6528/aae6aa

• theranostic
• ultrasound contrast agents
• hybrid liposome
• microbubbles
• near-infrared laser

Various nanoformulations of perfluorocarbon have been developed thus far, to achieve ultrasound imaging of tumors and tumor-targeted therapy. However, their application has been greatly limited by their short sonographic duration and large size distribution. A novel theranostic agent was constructed based on gold nanoshell cerasome-encapsulated L-menthol (GNC-LM). Owing to the sustained and controllable generation of L-menthol bubbles under near-infrared laser irradiation, GNC-LM showed good performance in contrast enhancement of ultrasound imaging in vivo. GNC-LM could be imaged for 30 min, which is much longer than the imaging time of SonoVue (commercially used microbubbles). Moreover, photothermal therapy (PTT) based on the light-to-heat conversion of the nanosystem effectively ablated the tumor. Our study demonstrated the promising potential of the obtained GNC-LM to serve as a therapeutic nanoprobe for ultrasound contrast imaging and PTT of tumors.

• 出版日期2019-1-4
• 单位中山大学