A polymorphism in human estrogen-related receptor beta (ESRR) predicts audiometric temporary threshold shift

作者：Bhatt Ishan^*; Phillips Susan; Richter Scott; Tucker Denise; Lundgren Kristine; Morehouse Robin; Henrich Vincent

来源：International Journal of Audiology, 2016, 55(10): 571-579.

DOI：10.1080/14992027.2016.1192693

• Noise-induced hearing loss (NIHL)
• Estrogen-Related Receptor Beta (ESRR)
• Temporary Threshold Shift (TTS)
• Otoacoustic Emissions (OAE)
• Single Nucleotide Polymorphism (SNP)

Objective: A non-synonymous single nucleotide polymorphism (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta (ESRR) showed possible association to noise-induced hearing loss (NIHL) in our previous study. Design: This study was conducted to examine the effect of the ESRR rs61742642 T variant on temporary threshold shift (TTS). TTS was induced by 10minutes of exposure to audiometric narrow-band noise centered at 2000Hz. Hearing thresholds and distortion product otoacoustic emissions input output DP IO) at 2000, 3000, and 4000Hz were measured before and after the noise exposure. Study sample: Nineteen participants with rs61742642 CT genotype and 40 participants with rs61742642CC genotype were recruited for the study. Results: Participants with the CT genotype acquired a significantly greater TTS without convincing evidence of greater DP IO temporary level shift (DPTLS) compared to participants with the CC genotype. Conclusion: The results indicated that the ESRR polymorphism is associated with TTS. Future studies were recommended to explore molecular pathways leading to increased susceptibility to NIHL.

• 出版日期2016