A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy

作者：Yu, Yongsheng; Li, Shuangdi; Wang, Kai^*; Wan, Xiaoping^*

来源：COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, 136-141, 2019.

DOI：10.1016/j.csbj.2019.01.002

• MDA-9/Syntenin
• PDZ domain
• Drug target
• Dimeric peptide
• Cancer

Melanoma differentiation-associated gene 9 (MDA-9)/Syntenin is a multidomain PDZ protein and identified as a key oncogene in melanoma initially. This protein contains a unique tandem PDZ domain architecture (PDZ1 and PDZ2 spaced by a 4-amino acid linker), an N-terminal domain (NTD) that is structurally uncharacterized and a short C-terminal domain (CTD). The PDZ1 domain is regarded as the PDZ signaling domain while PDZ2 served as the PDZ superfamily domain. It has various cellular roles by regulating many of major signaling pathways in numerous cancertypes. Through the use of novel drug design methods, such as dimerization and unnatural amino add substitution of inhibitors in our group, the protein may provide a valuable therapeutic target. The objective of this review is to provide a current perspective on the cancer-specific role of MDA-9/Syntenin in order to explore its potential for cancer drug discovery and cancer therapy.

• 出版日期2019
• 单位同济大学