Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients

作者：Naito Yuika; Ishii Masakazu^*; Nagamine Ayumu; Imagawa Atsuko; Shida Kenji; Takahashi Johji; Hosaka Yukiko; Naito Yuko; Oyamada Hideto; Shimizu Shunichi; Oguchi Katsuji; Hara Hajime; Masuda Yutaka; Usami Shino; Kiuchi Yuji

来源：Biological & Pharmaceutical Bulletin, 2010, 33(10): 1751-1753.

DOI：10.1248/bpb.33.1751

• migraine
• aura
• A-1438G polymorphism
• serotonin 2A receptor

We investigated the possible association of serotonin (5-HT) 2A receptor gene A-1438G polymorphism in Japanese patients with migraine. Genotyping of 5-HT2A A-1438G polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism in patients with migraine (male 17 : 3 with aura and 14 without aura, female 65: 17 with aura and 48 without aura) and controls (male 31, female 84). The distribution of 5-HT2A A-1438G genotype frequency between migraine patients and controls did not differ. These results suggest that the A-1438G polymorphism of the 5-HT2A receptor gene is not a direct risk factor for migraine; however, the incidence of the A/A genotype between migraine with aura (MA) and without aura (MO) was significantly different. The 5-HT2A A-1438G polymorphism may be involved in determining the subtypes of migraine in Japanese.

• 出版日期2010-10