Anti-inflammatory effects of pitavastatin in interleukin-1 beta-induced SW982 human synovial cells

作者：Cheng, Bin-Feng; Gao, Yao-Xin; Lian, Jun-Jiang; Guo, Dan-Dan; Liu, Tong-Tong; Xie, Yun-Fei; Wang, Lei; Yang, Hai-Jie; Wang, Mian^*; Feng, Zhi-Wei

来源：International Immunopharmacology, 2017, 50: 224-229.

DOI：10.1016/j.intimp.2017.06.032

• Pitavastatin
• IL-6
• IL-8
• Signaling pathway
• SW982 cells

The present study shows the basis for the anti-inflammatory effects of pitavastatin in interleukin (IL)-1 beta-induced human synovial cells. The SW982 cells were pretreated with pitavastatin at different concentrations (5 mu M and 10 mu M), followed by IL-1 beta (10 ng/mL) stimulation. The results showed that pitavastatin inhibited the expression of inflammatory mediators IL-6 and IL-8. Furthermore, pitavastatin inhibited the phosphorylation of p38, extracellular signal-related kinase (ERK), c-jun N-terminal kinase (JNK) and protein kinase B (Akt). It also suppressed the degradation of I kappa B alpha and blocked p65 translocation into the nucleus. These findings suggest that the mechanism underlying the inhibitory effects of pitavastatin on IL-1 beta-induced IL-6 and IL-8 release might be mediated by the suppression of mitogen-activated protein kinase (MAPK), Akt, and nuclear factor-kappa B (NF-kappa B) signaling pathways. These results may also indicate that pitavastatin may be potentially utilized as an effective therapeutic agent for the treatment of osteoarthritis.

• 出版日期2017-9
• 单位新乡医学院