Mineral-related hormones are closely associated with the titers of antibody against hepatitis B surface antigen in prevalent dialysis patients

作者：Chao Chia Ter^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(1): 1172-1178.

• End-stage renal disease
• ferritin
• fibroblast growth factor-23
• hepatitis B
• parathyroid hormone

Objectives: Hepatitis B virus infection confers a significant burden on patients with end-stage renal disease, but determinants of host reactivity against hepatitis B virus are still unclear. More importantly, the association between hepatitis B virus serologic reactivity and mineral-bone parameters has rarely been addressed. Methods: Chronic hemodialyzed patients with reactive anti-hepatitis B surface antigen antibody (anti-HBs antibody > 10 mIU/ml) were prospectively enrolled and analyzed. We performed correlation analysis between their anti-HBs antibody titers and mineral-related hormones as well as nutritional parameters. Significant associations were further investigated with regression analysis to validate the relationship after adjusting for potential confounding factors. Results: Among the chronic dialysis patients recruited, we found that anti-HBs antibody levels correlated significantly with intact parathormone (r=0.29; P=0.04), fibroblast growth factor-23 levels (r=0.27; P=0.049), and ferritin (r=-0.27; P=0.047) after adjustment for calcium, phosphate, and vitamin D levels. Linear regression analysis further showed that ferritin (P=0.03), intact parathormone (P<0.01), and fibroblast growth factor-23 (P=0.04) demonstrated significantly negative, positive, and positive associations with anti-HBs antibody titers in chronic dialysis patients, respectively. Conclusions: This pilot study suggests that mineral-regulating hormones including intact parathormone and fibroblast growth factor-23 might play a role in influencing the reactivity against hepatitis B virus in chronic dialysis patients.

• 出版日期2017