A Citric Acid-Derived Ligand for Modular Functionalization of Metal Oxide Surfaces via "Click" Chemistry

作者：Bishop Lee M; Yeager Joseph C; Chen Xin; Wheeler Jamie N; Torelli Marco D; Benson Michelle C; Burke Steven D; Pedersen Joel A; Hamers Robert J^*

来源：Langmuir, 2012, 28(2): 1322-1329.

DOI：10.1021/la204145t

Citric acid is a widely used surface-modifying ligand for growth and processing of a variety of nanoparticles; however, the inability to easily prepare derivatives of this molecule has restricted the development of versatile chemistries for nanoparticle surface functionalization. Here, we report the design and synthesis of a citric acid derivative bearing an alkyne group and demonstrate that this molecule provides the ability to achieve stable, multidentate carboxylate binding to metal oxide nanoparticles, while also enabling subsequent multistep chemistry via the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The broad utility of this strategy for the modular functionalization of metal oxide surfaces was demonstrated by its application in the CuAAC modification of ZnO, Fe2O3, TiO2, and WO3 nanoparticles.

• 出版日期2012-1-17