Assessment of the sedative effects of buprenorphine administered with 20 mu g/kg detomidine in horses

作者：Love E J^*; Taylor P M; Murrell J; Whay H R; Waterman Pearson A E

来源：The Veterinary Record, 2011, 168(15): 409-+.

DOI：10.1136/vr.c7315

The aim of this randomised, observer-blinded, crossover study was to compare the effects of four treatments, administered intravenously to six horses: saline and saline; 10 mu g/kg detomidine and 7.5 mu g/kg buprenorphine; 20 mu g/kg detomidine and 7.5 mu g/kg buprenorphine; and 20 mu g/kg detomidine and 10 mu g/kg buprenorphine. Sedation was subjectively assessed and recorded on a visual analogue scale. Peak sedation and duration of sedation were investigated using a univariate general linear model with post-hoc Tukey tests (P < 0.05). Increasing the dose of detomidine from 10 to 20 mu g/kg increased the degree of sedation when administered with the same dose of buprenorphine (7.5 mu g/kg). When administered with 20 mu g/kg detomidine, increasing the dose of buprenorphine from 7.5 to 10 mu g/kg did not influence the degree of sedation achieved.

• 出版日期2011-4-16