Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

作者：Sohtome Yoshihiro; Shimazu Tadahiro; Barjau Joaquin; Fujishiro Shinya; Akakabe Mai; Terayama Naoki; Dodo Kosuke; Ito Akihiro; Yoshida Minoru; Shinkai Yoichi; Sodeoka Mikiko^*

来源：Chemical Communications, 2018, 54(66): 9202-9205.

DOI：10.1039/c8cc03907k

We present a chemical methylome analysis platform to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone arginine methyltransferase inhibitor.

• 出版日期2018-8-25
• 单位RIKEN