A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

作者：Carr Anitra C^*; Bozonet Stephanie M; Pullar Juliet M; Simcock Jeremy W; Vissers Margreet C M

来源：Nutrients, 2013, 5(9): 3684-3695.

DOI：10.3390/nu5093684

• ascorbate
• ascorbic acid
• human
• plasma
• urine
• semen
• leukocytes
• skeletal muscle

Whether vitamin C from wholefoods has equivalent bioavailability to a purified supplement remains unclear. We have previously showed that kiwifruit provided significantly higher serum and tissue ascorbate levels than synthetic vitamin C in a genetically vitamin C-deficient mouse model, suggesting a synergistic activity of the whole fruit. To determine if these results are translatable to humans, we carried out a randomized human study comparing the bioavailability of vitamin C from kiwifruit with that of a vitamin C tablet of equivalent dosage. Thirty-six young non-smoking adult males were randomized to receive either half a gold kiwifruit (Actinidia Chinensis var. Hort 16A) per day or a comparable vitamin C dose (50 mg) in a chewable tablet for six weeks. Ascorbate was monitored weekly in fasting venous blood and in urine, semen, leukocytes, and skeletal muscle (vastus lateralis) pre- and post-intervention. Dietary intake of vitamin C was monitored using seven day food and beverage records. Participant ascorbate levels increased in plasma (P %26lt; 0.001), urine (P %26lt; 0.05), mononuclear cells (P %26lt; 0.01), neutrophils (P %26lt; 0.01) and muscle tissue (P %26lt; 0.001) post intervention. There were no significant differences in vitamin C bioavailability between the two intervention groups in any of the fluid, cell or tissue samples tested. Overall, our study showed comparable bioavailability of synthetic and kiwifruit-derived vitamin C.

• 出版日期2013-9