A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation

作者：Joy M Nibin; Savitha Bhaskaran; Sajith Ayyiliyath M^*; Bodke Yadav D^*; Venkatesh Talavara; Khader K K Abdul; Padusha M Syed Ali; Muralidharan A

来源：Chinese Chemical Letters, 2016, 27(1): 31-36.

DOI：10.1016/j.cclet.2015.08.015

• Imidazopyrazine
• Boronic acid
• Suzuki coupling
• Microwave

A rapid, efficient, and facile synthesis of an assortment of C-2 substituted imidazopyrazines has been achieved by utilizing the palladium catalyzed Suzuki cross-coupling of 2-bromo-1H-imidazo[4,5-b]pyrazine with various boronic acids under microwave irradiation. The utilization of (A-(ta)phos)(2)PdCI2 as a catalyst in combination with CsF as base and DME-H2O (4:1) as the solvent system at 100 degrees C procured the diaryls in acceptable to excellent yields. Prominent features of this developed methodology include short reaction times, fewer side products, and exceptional tolerance to a wide variety of functional groups.

• 出版日期2016-1