Adipokines: a link between obesity and dementia?

作者：Kiliaan Amanda J; Arnoldussen Ilse A C; Gustafson Deborah R^*

来源：Lancet Neurology, 2014, 13(9): 913-923.

DOI：10.1016/S1474-4422(14)70085-7

Being overweight or obese, as measured with body-mass index or central adiposity (waist circumference), and the trajectory of body-mass index over the life course have been associated with brain atrophy, white matter changes, disturbances of blood brain barrier integrity, and risk of all-cause late-onset dementia and Alzheimer%26apos;s disease. This observation leads us to question what it is about body-mass index that is associated with health of the brain and dementia risk. If high body-mass index and central adiposity represent an increase in adipose tissue, then the endocrine function of adipose tissue, mediated by adipose tissue hormones and adipokines, could be a due to mechanisms that underlie the association with dementia and Alzheimer%26apos;s disease. Hundreds of adipoldnes have been identified, creating a complexity that is a challenge to simplify. Nonetheless, adipokines are being investigated in association with clinical dementia outcomes, and with imaging-based measures of brain volume, structure, and function in human beings and in predinical models of clinical dementia.

• 出版日期2014-9