A one-pot, three-component, microwave-assisted synthesis of novel 7-amino-substituted 4-aminopyrazolo[1,5-alpha][1,3,5]triazine-8-carbonitriles

作者：Lim Felicia Phei Lin; Luna Giuseppe; Dolzhenko Anton V^*

来源：Tetrahedron Letters, 2015, 56(50): 7016-7019.

DOI：10.1016/j.tetlet.2015.11.006

• Triazine
• Pyrazole
• Purine isostere
• Multicomponent reaction
• Microwave irradiation

The synthesis of novel 7-amino-substituted pyrazolo[1,5-alpha][1,3,5]triazine-8-carbonitriles was achieved via a three-component reaction of 3-amino-substituted 5-aminopyrazole-4-carbonitriles, cyanamide and triethyl orthoformate under microwave irradiation. Under catalyst-free conditions, this three-component reaction accommodated a generous diversity of amino substituents making it ideal for the generation of compound libraries for drug discovery processes.

• 出版日期2015-12-16