Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients

作者：Zhu, Tao; Xie, Pan; Gao, Yuan-Feng; Huang, Ma-Sha; Li, Xi; Zhang, Wei; Zhou, Hong-Hao; Liu, Zhao-Qian^*

来源：CNS Neuroscience & Therapeutics, 2018, 24(3): 178-186.

DOI：10.1111/cns.12803

• gene expression profile
• Glioma
• NUSAP1
• pathological grade
• prognosis

AimsDespite therapeutic advances in glioma management including surgery, radiation, and chemotherapy, the improvement of patient outcome is far from satisfactory. Nucleolar and spindle-associated protein 1 (NUSAP1) is an important functional protein during mitosis, and its abnormal expression is implicated in progression of different types of tumors. However, the role of NUSAP1 in gliomas remains unclear. @@@ MethodsNUSAP1 expression in gliomas with different grades was investigated based on GEO glioma datasets. Kaplan-Meier survival analysis was used to evaluate its prognostic significance. In vitro assays were also performed to evaluate effects of NUSAP1 on malignant phenotypes of glioma cells by silencing NUSAP1. @@@ ResultsNUSAP1 expression was correlated not only with glioma grade but also with prognosis of glioma patients. NUSAP1 depletion suppressed proliferation of U251 cells by inducing cell cycle arrest at G2/M phase and apoptosis. NUSAP1 depletion rendered U251 cells impaired migratory ability as well. @@@ ConclusionNUSAP1 is a potential prognosis marker for glioma patients and therapeutic strategies targeting NUSAP1 might hold promise in improving glioma treatment.

• 出版日期2018-3
• 单位中南大学