Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans

作者：Illangasekera Yasitha A^*; Kumarasiri Ranjith P V; Fernando Devaka J; Dalton Caroline F

来源：Obesity Research & Clinical Practice, 2016, 10: S117-S124.

DOI：10.1016/j.orcp.2016.02.003

• FTO
• MC4R
• Single nucleotide polymorphism
• Obesity
• Sri Lankan

Objectives: To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans.
Methods: 535 subjects (60.9% female) from the general adult population (ages 18-70 years) representative of both urban (28.4%) and rural areas of residence were recruited by multi-stage random sampling. Body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) was obtained by standard methods. DNA extracted from whole blood was genotyped using real-time PCR.
Results: The FTO risk genotypes (AA + AT) were associated with higher BMI (p = 0.03) and WC (p = 0.05) measures as well as categorical obesity (BMI >= 27.5 kg m(-2) definition) (OR 1.69 95% CI 1.11-2.56, p = 0.01). The near MC4R risk genotypes (CC + CT) were associated with greater BMI (p = 0.03) as well as categorical obesity (BMI >= 25 kg m(-2) definition) (OR 1.57 95% CI 1.11-2.22, p = 0.01). In addition the MC4R risk genotype carriers (CC + CT) had significantly higher fasting blood sugar (FBS) levels compared to the 'TT' genotype carriers independent of BMI (p = 0.05). Urban living was associated with significantly greater BMI values for FTO risk genotypes compared to rural living (p = 0.02).
Conclusions: FTO and near MC4R variants are associated with obesity measures in Sri Lankan populations whilst urban living accentuates the obesogenic effect of the FTO polymorphism.

• 出版日期2016-9