Membrane rafts and caveolae in cardiovascular signaling

作者：Insel Paul A^*; Patel Hemal H

来源：Current Opinion in Nephrology and Hypertension, 2009, 18(1): 50-56.

DOI：10.1097/MNH.0b013e3283186f82

• caveolin
• endothelial nitric oxide synthase
• myocardial ischemia
• vascular endothelium
• vascular smooth muscle

Purpose of review
Substantial evidence documents the key role of lipid (membrane) rafts and caveolae as microdomains that concentrate a wide variety of receptors and postreceptor components regulated by hormones, neurotransmitters and growth factors.
Recent findings
Recent data document that these microdomains are important in regulating vascular endothelial and smooth muscle cells and renal epithelial cells, and particularly in signal transduction across the plasma membrane.
Summary
Raft/caveolae domains are cellular regions, including in cardiovascular and renal epithelial cells, which organize a large number of signal transduction components, thereby providing spatially and temporally efficient regulation of cell function.

• 出版日期2009-1