科研之友
微信
新浪微博
Facebook
分享链接
摘要
Photoactivatable groups meeting the criterion of minimal perturbance allow the investigation of interactions in biological samples. Here, we review the application of photoactivatable groups in lipids enabling the study of protein-lipid interactions in (biological) membranes. The chemistry of various photoactivatable groups is summarized and the specificity of the interactions detected is discussed. The recent introduction of 'click chemistry' in photocrosslinking of membrane proteins by photoactivatable lipids opens new possibilities for the analysis of crosslinked products and will help to close the gap between proteomics and lipidomics.
- 出版日期2009-8
