科研之友
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摘要
A highly regio-, diastereo-, and enantioselective 1,6-addition of azlactone to various alkenyl dienyl ketones has been achieved under P-spiro chiral triaminoiminophosphorane catalysis. This site-selectivity control relies on the distinct ability of the conjugate acids of iminophosphoranes, aminophosphonium ions, to precisely differentiate between the three electrophilic reaction sites of alkenyl dienyl ketones, which is further demonstrated by the discriminative asymmetric 1,6-addition of azlactone to dienyl ketones, leaving the coexisting alkenyl ketone intact.
- 出版日期2017-5-18
