Antagonistic effects of thiazolidinediones and cytokines in lipotoxicity

作者：Smith Ulf^*; Hammarstedt Ann

来源：Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 2010, 1801(3): 377-380.

DOI：10.1016/j.bbalip.2009.11.006

• Adipose tissue
• Obesity
• PPAR gamma
• Adipogenesis
• TNF alpha

Ectopic lipid accumulation is promoted by obesity and an impaired ability to accumulate triglycerides in the subcutaneous depots. The adipose tissue is dysregulated in hypertrophic obesity, i.e., when the adipose cells have become enlarged. In some individuals, however, obesity is a consequence of a recruitment of new adipocytes, i.e., a hyperplastic obesity. This form of obesity is usually not associated with the metabolic complications and is termed "obese but metabolically normal". We here review recent findings showing that hypertrophic obesity is associated with an impaired differentiation of committed preadipocytes. This may be a primary (genetic?) event, thus leading to hypertrophic fat cells and the associated inflammation. However, it is also possible that the inflammation is a primary event allowing, in particular, TNF alpha to inhibit preadipocyte differentiation. TNF alpha, instead, promotes a partial transdifferentiation of the preadipocytes to assume a macrophage-like phenotype. PPAR gamma activation promotes adipogenesis but can apparently not overcome the impaired preadipocyte differentiation seen in hypertrophic obesity.

• 出版日期2010-3