Neuropeptide Y and nestin expression in the hippocampal CA3 region following restrained and inverted stress in rats

作者：Sun, Guogang^*; Chen, Bo; Fan, Guangbi; Xiao, Hongwen; Chen, Yue; Xu, Jie; Nie, Ye; Zhang, Bing; Gong, Lin; Li, Ailing

来源：Neural Regeneration Research, 2011, 6(3): 206-212.

DOI：10.3969/j.issn.1673-5374.2011.03.008

• CA3 region
• learning and memory
• neuropeptide Y
• nestin
• restrained and inverted stress
• rats

Our preliminary study demonstrated that neuropeptide Y (NPY)/nestin-positive cells exhibit a consistent spatial distribution in the hippocampus of normal adult rats. However, following severe acute and chronic stress-induced impaired learning and memory, synchronous decreased expression of nestin and NPY takes place in the hippocampus, and the underlying mechanisms remain unclear. In the present study, acute and chronic stress rat models were established using combined restrained and inverted stress. Results showed that learning and memory significantly decreased in acute and chronic stress rats. In addition, hippocampal cells were damaged, in particular in the acute stress rats, and nestin and NPY expression, as well as the number of NPY/nestin-positive cells in the CA3 region, significantly decreased. Furthermore, mature neurofilament 200-positive neurons were absent in the chronic stress rats. The NPY and cytoskeletal protein system equally contributed to stress-induced early learning and memory deficits, as well as sustained cerebral injury in the adult hippocampus.

• 出版日期2011-1-25
• 单位中山大学; 西南医科大学