Development and validation of a multi-residue screening method for veterinary drugs, their metabolites and pesticides in meat using liquid chromatography-tandem mass spectrometry

作者：Wei, Huimin; Tao, Yanfei; Chen, Dongmei; Xie, Shuyu; Pan, Yuanhu; Liu, Zhenli; Huang, Lingli; Yuan, Zonghui^*

来源：Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure& Risk Assessment, 2015, 32(5): 686-701.

DOI：10.1080/19440049.2015.1008588

• screening
• veterinary anti-parasite drugs
• QuEChERS
• HPLC-MS/MS
• multi-residues

A rapid multi-residue screening method that includes 128 veterinary anti-parasitic drugs and metabolites in meat of chicken, porcine and bovine has been developed. The scope of the method focuses on screening the following main families of veterinary anti-parasitic drugs: avermectines, benzimidazoles, the polyether ionophore, anti-tapeworm, anti-trematode, anti-piroplasmosis and chemical classes of coccodiostats. The method described a QuEChERS sample preparation procedure prior to LC-MS/MS analysis. The modified QuEChERS technology minimises sample complexity and ion suppression effects. The method was validated according to European Union guidelines (2002/657/EC) for a quantitative screening method. The validation results demonstrate that the described LC-MS/MS method provides sensitive, repeatable and meets residue screening monitoring requirements.

• 出版日期2015-5-4
• 单位华中农业大学