Novel multi-component syntheses of pyrimidines using beta-CD in aqueous medium

作者：Chowrasia Rakhi; Katla Ramesh^*; Darbem Mariana P; Branquinho Tabata A; de Oliveira Aline Rufino; Manjari Padma Sunitha^*; Domingues Nelson Luis C^*

来源：Tetrahedron Letters, 2016, 57(15): 1656-1660.

DOI：10.1016/j.tetlet.2016.02.106

• Aldehydes
• Ammonium acetate
• 1,3-Dicarbonyl compounds
• beta-Cyclodextrin
• Pyrimidines
• Water

Using beta-cyclodextrin (beta-CD) as a catalyst pyrimidine derivatives were synthesized for the first time in aqueous medium. beta-CD is a recyclable, inexpensive, economically viable, non-toxic, and readily available material. Various aldehydes were used with ammonium acetate, and 1,3-diketones to generate a series of pyrimidine derivatives in good to excellent yields.

• 出版日期2016-4-13