Determination of Midazolam by Potentiometric PVC membrane and MWCNTs based Carbon Paste Sensors

作者：Ganjali Mohammad Reza^*; Larijani Bagher; Norouzi Parviz

来源：International Journal of Electrochemical Science, 2012, 7(5): 4822-4833.

• Midazolam
• Potentiometric Sensor
• PVC membrane Electrode
• Nano-composite Carbon Paste electrode
• Ion-Pair

PVC membrane and nano-composite carbon paste potentiometric sensors were made for determination of midazolam in pharmaceutical formulations. The electrodes respond based on ion-exchange mechanism. The ion-pair used as a sensing element in PVC membrane and carbon paste compositions was synthesized by interaction of midazolam and tetraphenyl borate. The best PVC membrane sensor response was obtained by a membrane composition of 30% PVC, 65% DBP, and 5% ion-pair. Carbon paste electrode was then designed to have an electrode with the better mechanical resistance. The best electrode was composed of 20% ion-pair, 20% paraffin oil, 5% MWCNTs and 55% graphite. The proposed method was successfully applied in determination of Midazolam in the pharmaceutical formulations.

• 出版日期2012-5