Nucleophilic ring-opening reaction of benzoxazinones-access to o-amino-2,2,2-trifluoroacetophenones

作者：Allendoerfer Nadine; Es Sayed Mazen; Nieger Martin; Braese Stefan

来源：Tetrahedron Letters, 2012, 53(4): 388-391.

DOI：10.1016/j.tetlet.2011.11.014

• Fluorine
• Trifluoromethylation
• Benzoxazinones
• Ruppert%26apos
• s reagent

Organofluorine compounds are of high interest in modern drug discovery and material sciences. We herein report a new synthetic access to o-amino-2,2,2-trifluoroacetophenones starting from commercially available o-amino benzoic acids, which can easily be converted into the corresponding benzoxazinones. In a second step the trifluoromethylated ketone is formed via addition of Ruppert%26apos;s reagent following acidic work up.

• 出版日期2012-1-25