Association of Vitamin D with outcome after intra cytoplasmic sperm injection

作者：Abdullah Umme Hani; Lalani Salima; Syed Fatima; Arif Sara; Rehman Rehana^*

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2017, 30(1): 117-120.

DOI：10.3109/14767058.2016.1163680

• Assisted reproductive techniques
• Infertility
• intracytoplasmic sperm injection (ICSI)
• Vitamin D

Objective: To observe effects of vitamin D levels on pregnancy outcome after intra cytoplasmic sperm injection (ICSI).
Method: It was a cross-sectional study conducted in Australian Concept Infertility Medical Center from July 2011 to August 2014. Estimation of 25-hydroxy cholecalciferol (25-OHD) of consented females (252) was done before treatment protocol for ICSI. Results of beta hCG performed 14 days after embryo transfer categorized groups; Pregnant with beta hCG more than 25 IU/mL and rest included in non-pregnant group. Both groups were compared by independent sample t-test and Pearson's Chi Square test. Binary Logistic Regression Analysis was used to estimate odds ratio of pregnancy outcome with its predictors including Vitamin D.
Results: The mean value of 25-OHD, number of oocytes, fertilized oocytes and endometrial thickness was significantly higher in pregnant women. A significant positive association of 25-OHD with clinical pregnancy and thickness of endometrium was observed. After adjustment with female age and BMI, positive association of vitamin D with endometrial thickness was observed.
Conclusion: Deficiency of 25-OHD in females hinders the accomplishment of optimal endometrial thickness required for implantation of embryo after ICSI. The improvement in vitamin D status can thus improve success results in assisted reproductive clinics.

• 出版日期2017-1