Association of interleukin-1A insertion/deletion gene polymorphism and possible high risk factors with non-alcoholic fatty liver disease in Egyptian patients

作者：Abdel Hamed Asmaa R^*; Ghattas Maivel H; Me**ah Noha M; Saleh Samy M; Abo Elmatty Dina M

来源：Archives of Physiology and Biochemistry, 2017, 123(5): 330-333.

DOI：10.1080/13813455.2017.1339717

• IL-1A insertion deletion gene polymorphism
• non-alcoholic fatty liver disease

Context: Interleukin-1A (IL-1A) is a cytokine involved in inflammatory process. IL-1A (rs3783553) gene polymorphism is comprised in the regulation of IL-1A expression.
Objective: This study aims to evaluate association of IL-1A (I/D) gene polymorphism with NAFLD and its component traits among Egyptian populations.
Methods: The study included 75 healthy subjects and 75 patients with NAFLD. Different genotypes of IL-1A (I/D) gene polymorphism were determined by PCR-PAGE technique, serum IL-1A level and other biochemical parameters were measured.
Results: The major D allele was significantly associated with NAFLD patients (p=.002). DD genotype showed a significant increase in BMI and decrease in HDL-C. Also serum IL-1A was significantly correlated with the DD genotype. Serum IL-1A showed a significant positive correlation with BMI, triglycerides, total cholesterol, LDL-C, VLDL-C and FBG, and a significant negative correlation with HDL-C.
Conclusions: Major D allele of IL-1A (I/D) gene polymorphism is associated with NAFLD in the Egyptian population.

• 出版日期2017