Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: Design, synthesis and biological evaluation

作者：Shi Liqiao; Hui Rui; Wei Yanhong; Liang Ying; Yang Ziwen; Ke Shaoyong^*

来源：European Journal of Medicinal Chemistry, 2012, 54: 549-556.

DOI：10.1016/j.ejmech.2012.06.001

• Anthranilic diamides
• Aryl-isoxazoline
• Synthesis
• Antitumor activity

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by H-1 NMR, C-13 NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at mu M level, which might be developed as novel lead scaffold for potential anticancer agents.

• 出版日期2012-8
• 单位湖北省生物农药工程研究中心