An easy access to halogenated and non-halogenated spiro-hexadienones

作者：Martins Lucimara J; Ferreira Bruno R V; Almeida Wanda P; Lancellotti Marcelo; Coelho Fernando^*

来源：Tetrahedron Letters, 2014, 55(38): 5264-5267.

DOI：10.1016/j.tetlet.2014.07.114

• Morita-Baylis-Hillman
• Spiro-hexadienones
• Heck reaction
• Hypervalent iodine
• Brominated compounds

We describe an improved protocol for the synthesis of spiro-hexadienones from Morita-Baylis-Hillman adducts. Solvent modification and temperature resulted in a significant increase in the yield. This protocol was used to synthesize mono- and dibrominated spiro-hexadienones in good overall yields. This report is the first to describe the synthesis of halogenated spiro-hexadienones from Morita-Baylis-Hillman adducts.

• 出版日期2014-9-17