Association between RAD51 gene polymorphism (-135G/C) and susceptibility of myelodysplastic syndrome and acute leukemia: evidence based on a meta-analysis

作者：He, Ya-zhou; Hu, Xin; Chi, Xiao-sa; Zhang, Yuan-chuan; Deng, Xiang-Bing; Wei, Ming-tian; Wang, Zi-qiang; Zhou, Yan-hong^*

来源：Tumor Biology, 2014, 35(1): 615-621.

DOI：10.1007/s13277-013-1085-4

• RAD51-135G/C
• Myelodyspastic syndrome
• Acute leukemia
• Meta-analysis

Study results on the association between RAD51 gene -135G/C polymorphism and risk of myelodysplastic syndrome (MDS) or acute leukemia are inconsistent. A meta-analysis was conducted to identify the association. A systematic search was performed in PubMed, Embase, CNKI, VIP, Wanfang databases to collect all relevant studies until January 2013. Meta-analysis was carried out using fixed/random model by Review Manager 5.1 and STATA10.0. A total of 10 eligible studies with 2,656 patients and 3,725 controls were included in meta-analysis. Significant association was detected between -135G/C polymorphism and increased MDS risk (CC + GC vs. GG: OR = 1.46, 95 % CI = 1.11-1.92; CC vs. GC + GG: OR = 2.45, 95 % CI = 1.23-4.89), while no association was observed for acute leukemia. Subgroup analysis by subtypes of acute leukemia and ethnicity showed no significant results either. Our meta-analysis indicated that the -135G/C polymorphism might be associated with increased susceptibility of MDS. However, lack of evidence supported association of this polymorphism with acute leukemia. Additional well-designed studies with larger samples are required to verify our results.

• 出版日期2014-1
• 单位四川大学