An Optimized Process to 10-Bromo-1-decanol

作者：Spaccini Raffaele^*; Tsoukala Anna; Liguori Lucia; Punta Carlo; Bjorsvik Hans Rene

来源：Organic Process Research & Development, 2010, 14(5): 1215-1220.

DOI：10.1021/op100143t

A multivariate design and optimization study for the synthesis of the bromoalklmol 10-bromo-1-decanol using decane-1,10-diol as substrate is reported. The bromination process was supported by the phase transfer catalyst tetrabutylammonium bromide with aqueous HBr (48%) as the brominating reagent. The optimized batch protocol provided a yield of 64% of 10-bromo-1-decanol 2 TM with a conversion of 80%, and 10% of the dibrominated alkane 1,10-dibromodecane 3, a characteristic byproduct, was formed.

• 出版日期2010-10