Molecular iodine mediated one step synthesis of 3-substituted-6-(6-substituted-2-oxochromen-3-yl)-7H[1,2,4]triazolo[3,4- b][1,3,4]thiadiazines

作者：Jakhar Anshu; Makrandi Jagdish K^*

来源：Journal of Chemical Research, 2010, (4): 238-240.

DOI：10.3184/030823410X12715064952719

• 6-(6-substituted-2-oxochromen-3-yl)-7H[1,2,4triazolo[3,4-b][1,3,4thiadia zines
• molecular iodine
• 3-acetylcoumarin

Iodine mediated condensation of 3-acetyl-6-substitutedcoumarin (1) with 3-alkyl/aryl-4-amino-5-mercapto[1,2,4]triazoles (2) have been found to give 3-alkyl/aryl-6-(6-substituted-2-oxochromen-3-yl)-7H [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines (3a-n) directly in one step. The reaction has also been carried out using microwave irradiation. This protocol is an improvement on reported methods as it occurs in a single step and avoids the use of highly lachrymatory molecular bromine.

• 出版日期2010-4