MicroRNAs as a New Potential Therapeutic Opportunity in Gastrointestinal Cancer

作者：Boni V^*; Bandres E; Zarate R; Colucci G; Maiello E; Garcia Foncillas J

来源：Oncology, 2009, 77(1): 75-89.

DOI：10.1159/000258499

• Cancer
• MicroRNA-based therapy
• Oncogenes
• Small interfering double-stranded RNA
• Tumor suppressor genes

MicroRNAs (miRNAs) comprise an abundant class of small non-coding RNAs that act as important post-transcriptional regulators of gene expression. Accumulating evidence shows that aberrantly expressed miRNAs play important roles in human cancers and underscores them as potential targets for therapeutic intervention. Basic research has provided strong evidence about the role of miRNA as oncogenes and as tumor suppressor genes in cancer. In accord with this finding, miRNA-based cancer therapy is a very interesting field of investigation that offers the appeal of targeting multiple gene networks controlled by a single, aberrantly expressed miRNA. A new door in cancer research is opening and it may lead to the modulation of miRNAs.

• 出版日期2009