A Simple and Efficient Synthesis of 3,4,5-Trisubstituted/N-Fused 1,2,4-Triazoles via Ceric Ammonium Nitrate Catalyzed Oxidative Cyclization of Amidrazones with Aldehydes Using Polyethylene Glycol as a Recyclable Reaction Medium

作者：Nakka Mangarao; Tadikonda Ramu; Rayavarapu Srinuvasarao; Sarakula Prasanthi; Vidavalur Siddaiah^*

来源：Synthesis (Germany), 2015, 47(4): 517-525.

DOI：10.1055/s-0034-1378909

• polyethylene glycol
• ceric ammonium nitrate
• 1,2,4-triazoles
• [1,2,4]triazolo[4,3-a]pyridines
• [1,2,4]triazolo[4,3-a]pyrazines

An environmentally benign protocol is described for the synthesis of 3,4,5-trisubstituted 1,2,4-triazoles and N-fused 1,2,4-triazoles via ceric ammonium nitrate catalyzed oxidative cyclization of amidrazones and aldehydes using polyethylene glycol as recyclable reaction medium. This protocol is effective toward various substrates having different functionalities. The easy recyclability of the reaction medium makes the process economic and potentially viable for commercial applications.

• 出版日期2015-2