NABTT 0502: a phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme

作者：Peereboom David M^*; Ahluwalia Manmeet S; Ye Xiaobu; Supko Jeffrey G; Hilderbrand Sarah L; Phuphanich Surasak; Nabors L Burt; Rosenfeld Myrna R; Mikkelsen Tom; Grossman Stuart A

来源：Neuro-Oncology, 2013, 15(4): 490-496.

DOI：10.1093/neuonc/nos322

• EGFR
• erlotinib
• pharmacokinetics
• glioblastoma
• Ras signaling
• sorafenib
• targeted therapy

The signal transduction pathways of epidermal growth factor receptor and Ras are both important in the growth of glioblastoma multiforme (GBM). We hypothesized that inhibition of both pathways would improve the survival time of patients with recurrent GBM. %26lt;br%26gt;Patients with recurrent/progressive GBM with 02 prior chemotherapy regimens received erlotinib 150 mg once daily and sorafenib 400 mg twice daily until progression. The primary endpoint was overall survival. Pharmacokinetic sampling was performed during cycle 1. %26lt;br%26gt;The median overall survival was 5.7 months. Progression-free survival at 6 months was 14. Toxicity was manageable. Clearance of erlotinib was markedly enhanced by sorafenib. %26lt;br%26gt;The study did not meet its objective of a 30 increase in overall survival time compared with historical controls. Erlotinib and sorafenib have significant pharmacokinetic interactions that may negatively impact the efficacy of the combination regimen.

• 出版日期2013-4