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A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging
Zou Xiao Ju
Ma Yi Cheng
Guo Lin E
Liu Wen Xiang
Liu Mei Juan
Zou Cheng Gang
Zhou Ying
Zhang Jun Feng
Chemical Communications, 50(89), pp 13833-13836, 2014
Summary
A lysosome-targeted fluorescent chemodosimeter, 1, was developed for monitoring endogenous and exogenous H2S by in vivo imaging of HeLa cells, D. melanogaster and C. elegans. In the tests of mutated C. elegans (SRP-6 nulls), chemodosimeter 1 could trace the accumulation of lysosome and lysosomal injury with a high resolution.
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