A new and potent class of quinoline derivatives against cancer

作者：Bispo Marcelle de L F; de Alcantara Camila C; de Moraes Manoel O; Pessoa Claudia do O; Rodrigues Felipe A R; Kaiser Carlos R; Wardell Solange M S V; Wardell James L; de Souza Marcus V N^*

来源：Monatshefte fur Chemie, 2015, 146(12): 2041-2052.

DOI：10.1007/s00706-015-1570-0

• Drug research
• Antitumor agents
• Heterocycles
• Hydrazones
• Quinoline compounds

A new class of 4-quinolinylhydrazone derivatives has been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using the MTT assay. Compounds displaying more than 90 % of growth inhibition were evaluated for in vitro anticancer activities against four human cancer cell lines. The results were expressed as the concentrations that induce 50 % inhibition of cell growth (IC50) in mu g/cm(3). These compounds exhibited good cytotoxic activity against at least three cancer cell lines, with IC50 values between 0.314 and 4.65 mu g/cm(3). These derivatives are useful starting points for further study for new anticancer drugs and confirm the potential of quinoline derivatives as lead compounds in anticancer drug discovery.

• 出版日期2015-12