Why is there so much CD45 on T cells?

作者:Zamoyska Rose*
来源:Immunity, 2007, 27(3): 421-423.
DOI:10.1016/j.immuni.2007.08.009

摘要

The balance between kinases and phosphatases is crucial for regulating lymphocyte signaling. In this issue, McNeill et al. (2007) show that the transmembrane phosphatase CD45 has a role as both positive and negative regulator of T cell signaling.