Mineral and bone disorders in kidney transplant recipients: reversible, irreversible, and de novo abnormalities

作者：Hirukawa Takashi; Kakuta Takatoshi; Nakamura Michio; Fukagawa Masafumi^*

来源：Clinical and Experimental Nephrology, 2015, 19(4): 543-555.

DOI：10.1007/s10157-015-1117-z

• Bone
• Parathyroid
• CKD-MBD
• Kidney transplantation
• Calcium
• Phosphorus

Given the advances in medical technologies related to kidney transplantation, the post-transplant graft survival rate and quality of life have improved dramatically. Nevertheless, post-transplant mortality rate still remains high as compared to the general population due to the development of cardiovascular events. It has recently been widely recognized that chronic kidney disease-mineral and bone disorders (CKD-MBD) significantly contribute to such poor prognosis at least in part. In the majority of kidney recipients, abnormal serum parameters for mineral and bone disorder (MBD), such as phosphorus, calcium, 1,25-dihydroxyvitamin D, parathyroid hormone and fibroblast growth factor 23, gradually return toward acceptable levels following the re-establishment of kidney function after transplantation; however, some irreversible abnormalities, developed as the result of long-term dialysis, persist, require treatment, or even progress after kidney transplantation. Thus, better management of CKD-MBD during pre-dialysis and dialysis period as well as after kidney transplantation is highly appreciated.

• 出版日期2015-8