Aqueous media preparation of 2-amino-4,6-diphenylnicotinonitriles using cellulose sulfuric acid as an efficient catalyst

作者：Mansoor Syed Sheik^*; Aswin Krishnamoorthy; Logaiya Kuppan; Sudhan Prasanna Nithiya; Malik Saleem

来源：Research on Chemical Intermediates, 2014, 40(2): 871-885.

DOI：10.1007/s11164-012-1008-9

• Cellulose sulfuric acid
• 2-Amino-4,6-diphenylnicotinonitrile
• Catalyst recovery
• Aqueous media preparation

A convenient approach to the synthesis of 2-amino-4,6-diphenylnicotinonitriles via four-component reaction of aromatic aldehydes, acetophenone derivatives, malononitrile and ammonium acetate is described. The reactions were done in water as solvent using cellulose sulfuric acid as catalyst. This simple protocol offer advantages such as shorter reaction times, simple work-up procedure, excellent yields and catalyst recovery.

• 出版日期2014-2