A Meta-Analysis of Coffee Intake and Risk of Urolithiasis

作者：Wang, Shuai; Zhang, Yuelong; Mao, Zujie; He, Xiang; Zhang, Qi; Zhang, Dahong^*

来源：Urologia Internationalis, 2014, 93(2): 220-228.

DOI：10.1159/000356559

• Coffee
• Urolithiasis
• Meta-analysis
• Cohort
• Case-control

Objective: Epidemiologic studies have reported various results relating coffee to urolithiasis. A meta-analysis of cohort and case-control studies was conducted to pool the relative risk (RR) estimates of the association between coffee and urolithiasis. Methods: Eligible studies were retrieved via both computer searches and review of references. We analyzed abstracted data with random effects models to obtain the summary RR estimates. A dose-response meta-analysis was performed for studies reporting categorical RR estimates for a series of exposure levels. Results: A total of 6 studies (2 cohort and 4 case-control studies) on coffee intake were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest coffee consumption (OR = 0.70, 95% confidence interval 0.60-0.82) on the risk of urolithiasis. Coffee exhibited an inverse dose-response relationship with urolithiasis. In stratified analysis, a significant inverse association between coffee and urolithiasis was observed in study design, geographical region and gender subgroup. Conclusions: The overall current literature suggests that coffee intake is associated with a decreased risk of urolithiasis. Further efforts should be made to clarify the underlying biological mechanisms.

• 出版日期2014
• 单位浙江大学; 浙江省人民医院