A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention

作者：Ewing Sarah W Feldstein^*; Mead Hilary K; Yezhuvath Uma; DeWitt Sam; Hutchison Kent E; Filbey Francesca M

来源：Psychiatry Research: Neuroimaging , 2012, 204(2-3): 112-116.

DOI：10.1016/j.pscychresns.2012.10.011

• Cannabis
• Client language
• Genetics
• fMRI
• Adolescents

Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.

• 出版日期2012-11-30