Arginase I Suppresses IL-12/IL-23p40-Driven Intestinal Inflammation during Acute Schistosomiasis

作者：Herbert De'Broski R^*; Orekov Tatyana; Roloson Amanda; Ilies Monica; Perkins Charles; O'Brien William; Cederbaum Stephen; Christianson David W; Zimmermann Nives; Rothenberg Marc E; Finkelman Fred D

来源：The Journal of Immunology, 2010, 184(11): 6438-6446.

DOI：10.4049/jimmunol.0902009

Alternatively activated macrophages prevent lethal intestinal pathology caused by worm ova in mice infected with the human parasite Schistosoma mansoni through mechanisms that are currently unclear. This study demonstrates that arginase I (Arg I), a major product of IL-4- and IL-13-induced alternatively activated macrophages, prevents cachexia, neutrophilia, and endotoxemia during acute schistosomiasis. Specifically, Arg I-positive macrophages promote TGF-beta production and Foxp3 expression, suppress Ag-specific T cell proliferation, and limit Th17 differentiation. S. mansoni-infected Arg I-deficient bone marrow chimeras develop a marked accumulation of worm ova within the ileum but impaired fecal egg excretion compared with infected wild-type bone marrow chimeras. Worm ova accumulation in the intestines of Arg I-deficient bone marrow chimeras was associated with intestinal hemorrhage and production of molecules associated with classical macrophage activation (increased production of IL-6, NO, and IL-12/IL-23p40), but whereas inhibition of NO synthase-2 has marginal effects, IL-12/IL-23p40 neutralization abrogates both cachexia and intestinal inflammation and reduces the number of ova within the gut. Thus, macrophage-derived Arg I protects hosts against excessive tissue injury caused by worm eggs during acute schistosomiasis by suppressing IL-12/IL-23p40 production and maintaining the Treg/Th17 balance within the intestinal mucosa. The Journal of Immunology, 2010, 184: 6438-6446.

• 出版日期2010-6-1