Absence of the Effect of Pretransplant Body Mass Index on Post Kidney Transplant Outcomes

作者：Tremblay Simon^*; Kaiser Tiffany E; Alloway Rita R; Woodle E Steve; Diwan Tayyab S

来源：Progress in Transplantation, 2016, 26(2): 183-190.

DOI：10.1177/1526924816640679

• complications
• delayed graft function
• live donors
• obesity
• outcome
• rejection

Context: Obesity has been reported as risk factor for reduced posttransplant graft and patient survival and increased delayed graft DGF). Objective: The purpose of this work is to analyze the effect of body mass index (BMI) on defined transplant outcomes in patients transplanted under defined guidelines in a kidney transplant program. Design: Review of a prospectively collected database in renal transplant recipients receiving rabbit antithymocyte globulin induction, mycophenolate mofetil, tacrolimus, and early corticosteroid withdrawal between 2001 and 2011. Setting: This review was conducted in a single abdominal transplant program in the United States. Main Outcome Measures: Primary outcome was death-censored graft survival categorized by posttransplant body mass groups. Secondary outcomes included DGF as well as patient survival. Results: Four hundred sixty seven patients were identified. No difference was observed in graft survival or DGF between BMI groups. One-year, death-censored graft survival and patient survival rates ranged from 97.5% to 100% and 96.6% to 100%, respectively. Delayed graft function was uncommon across all BMI groups, ranging from 5.3% to 9.1%, with the lowest incidence in patients with a BMI >= 35 kg/m(2). Biopsy-proven acute rejection rates at 1 year were similar across all groups (10.1%-14%) as were estimated glomerular filtration rates were at 1, 3, and 5 years. Conclusion: Our results do not show an effect of BMI on posttransplant outcomes, suggesting that relaxation of BMI criteria may be warranted for recipient selection.

• 出版日期2016-6