Deuterium Reveals the Dynamics of Notch Activation

作者：Raphael Kopan^*

来源：Structure, 2011, 19(4): 443-444.

DOI：10.1016/j.str.2011.03.006

Notch activation requires unfolding of a juxtamembrane negative regulatory domain (NRR). Tiyanont et al. (2011) analyzed the dynamics of NRR unfolding in the presence of EGTA. As predicted from the crystal structure and deletion analyses, the lin-Notch repeats unfold first, facilitating access by ADAM proteases. Surprisingly, the heterodimerization domain remains stable.

• 出版日期2011-4-13