A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO

作者：Fan, Jing; He, Nongyue^*; He, Qianjun; Liu, Yi; Ma, Ying; Fu, Xiao; Liu, Yijing; Huang, Peng; Chen, Xiaoyuan

来源：Nanoscale, 2015, 7(47): 20055-20062.

DOI：10.1039/c5nr06630a

• NITRIC-OXIDE
• GRAPHENE OXIDE
• DELIVERY
• EFFICIENT
• MULTIPLICATION
• NANOPARTICLES
• DOXORUBICIN
• GENERATION
• EXCITATION

A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the pi-pi stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.

• 出版日期2015
• 单位生物电子学国家重点实验室; 深圳大学; 广西壮族自治区南溪山医院; 东南大学