An O2 Self-Supplementing and Reactive-Oxygen-Species-Circulating Amplified Nanoplatform via H2O/H2O2 Splitting for Tumor Imaging and Photodynamic Therapy

作者：Zhang, Chi; Chen, Wei-Hai; Liu, Li-Han; Qiu, Wen-Xiu; Yu, Wu-Yang; Zhang, Xian-Zheng^*

来源：Advanced Functional Materials, 2017, 27(43): 1700626.

DOI：10.1002/adfm.201700626

• hypoxic tumors
• photodynamic therapy
• reactive oxygen species
• upconversion nanoparticles
• water-splitting

Conventional photodynamic therapy (PDT) has limited applications in clinical cancer therapy due to the insufficient O-2 supply, inefficient reactive oxygen species (ROS) generation, and low penetration depth of light. In this work, a multifunctional nanoplatform, upconversion nanoparticles (UCNPs)@TiO2@MnO2 core/shell/sheet nanocomposites (UTMs), is designed and constructed to overcome these drawbacks by generating O-2 in situ, amplifying the content of singlet oxygen (O-1(2)) and hydroxyl radical (center dot OH) via water-splitting, and utilizing 980 nm near-infrared (NIR) light to increase penetration depth. Once UTMs are accumulated at tumor site, intracellular H2O2 is catalyzed by MnO2 nanosheets to generate O-2 for improving oxygen-dependent PDT. Simultaneously, with the decomposition of MnO2 nanosheets and 980 nm NIR irradiation, UCNPs can efficiently convert NIR to ultraviolet light to activate TiO2 and generate toxic ROS for deep tumor therapy. In addition, UCNPs and decomposed Mn2+ can be used for further upconversion luminescence and magnetic resonance imaging in tumor site. Both in vitro and in vivo experiments demonstrate that this nanoplatform can significantly improve PDT efficiency with tumor imaging capability, which will find great potential in the fight against tumor.

• 出版日期2017-11-17
• 单位武汉大学