Asymmetric Synthesis of Medium-Sized Rings by Intramolecular Au(I)-Catalyzed Cyclopropanation

作者：Watson Iain D G; Ritter Stefanie; Toste F Dean^*

来源：Journal of the American Chemical Society, 2009, 131(6): 2056-+.

DOI：10.1021/ja8085005

An efficient method for the asymmetric gold (I)-catatyzed preparation of medium sized rings has been developed. The method provides 7- to 9-membered rings in excellent yield. High enantioselectivities can be achieved for 7- and 8-membered ring products employing chiral gold(I) complexes. The results provide insight into the mechanism, showing the fluxional nature of gold (I)-stabilized vinyl carbenoid intermediates.

• 出版日期2009-2-18